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Acute phase protein quantitation in serum samples from healthy Atlantic bottlenose dolphins (Tursiops truncatus)

Author(s): Cray, C.; K.L. Arheart; M. Hunt; T. Clauss; L.L. Leppert; K. Roberts; S.D. McCulloch; J.D. Goldstein; C. Gonzalez; J. Sweeney; R. Stone; P.A. Fair; G.D. Bossart


Publication Type: Journal Article

Journal Title: Journal of Veterinary Diagnostic Investigation

Date of Publication: 2013

Reference Information: 25(1): 107-111

Keywords: Acute phase protein; acute phase response; bottlenose dolphin; C-reactive protein; haptoglobin; inflammation; serum amyloid A

Abstract: Acute phase proteins have been studied in many companion and large animals and have been reported to have a differential sensitivity to traditional markers of inflammation. Studies have been performed indicating the conservation of these proteins as well as the application and cross reactivity of automated assays among different species but few reports have detailed acute phase proteins in marine mammal species. In the present study, automated assays were utilized to generate reference intervals for C-reactive protein, haptoglobin, and serum amyloid A using 44 serum samples from healthy dolphins. Twenty-five samples were obtained from dolphins under human care and 19 samples were obtained from free-ranging dolphins. Mild yet statistically significant differences were observed in levels of haptoglobin and serum amyloid A between these groups. The reference intervals from the combined groups were as follows: C-reactive protein 3.1-19.7 mg/L, haptoglobin 0-0.37mg/ml, and serum amyloid A 17.5-42.9 mg/L. This baseline data should provide an important foundation for future studies of the application of acute phase protein quantitation in monitoring the health and stressors of dolphins under human care and free-ranging dolphins.