Publication Details
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Structure revision of trichotoxin, a chlorinated polyketide isolated from a Trichodesmium thiebautii bloom
Author(s): Bertin, M.J.; P.V. Zimba; H. He; P.D.R. Moeller
NCCOS Center: HML
Publication Type: Journal Article
Journal Title: Elsevier(Tetrahedron Letters)
Date of Publication: 2016
Reference Information: 57(52):
5864-5867
Abstract: NMR-guided fractionation of the lipophilic extract of Trichodesmium thiebautii filaments led to the isolation of a phenyl-containing chlorinated polyketide (1) and an alkyne-containing analog (2). Comparison of spectroscopic and spectrometric data of 1 with the data of the previously reported trichotoxin, strongly suggested that these metabolites were identical and supports a structural revision of trichotoxin and its designation as trichotoxin A. In addition, we report the isolation and characterization of the alkyne-containing analog trichotoxin B (2). Absolute configuration of 1 and 2 is proposed based on spectroscopic comparison to a close structural analog.
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